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To date, interrogation of the interplay between infected cells and the immune system at sites of COVID-19 infection remains lacking. This webcast will describe use of high-parameter Imaging Mass Cytometry^™ to target the expression of 36 proteins, to investigate the cellular composition and spatial architecture of human acute lung injury including SARS-CoV-2 at single cell resolution.

This spatially resolved, single-cell data unravels the disordered structure of the infected and injured lung alongside the distribution of extensive immune infiltration. Leveraging the temporal range of COVID-19 severe fatal disease in relation to the time of symptom onset revealed increased macrophage extravasation, mesenchymal cells, and fibroblasts abundance concomitant with increased proximity between these cell types as the disease progresses, possibly as an attempt to repair the damaged lung tissue.

A biologically interpretable landscape of lung pathology from a structural, immunological and clinical standpoint was developed, enabling the pathophysiological characterization of the human lung from its macroscopic presentation to the single cell, providing an important basis for the understanding of COVID-19, and lung pathology in general.

Learn about:

• How COVID affects lung tissue composition and architecture, at single cell resolution, in the course of the disease
• How the effect of COVID on the lung differs from other lung infections and respiratory diseases
• Which cell types SARS-Cov2 targets in the lung and what pathways are triggered by infection in infected cells and neighboring cells