Insufficient sleep visually translates in a tired and unhealthy look with hanging eyelids, swollen eyes and dark circles. Internally, there is a decompensation of circadian hormones, a chronic low inflammation and an increase of glycemia. LipoTrue presents a peptide that modulates the exaggerated inflammatory response of alarmin IL-33, acts as a melatonin-like, and it protects skin’s proteins from glycation due to hyperglycemia.