The Research Institute for Fragrance Materials, Inc. (RIFM) has evaluated safety data for fragrance materials for over 55 years. In 2015, RIFM captured its safety assessment process in the peer-reviewed document Criteria II (Food and Chemical Toxicology). A series of decision trees, reflecting advances in risk assessment approaches of mixtures and toxicological methodologies, follows a tiered approach for each endpoint using a 4-step process with testing only as a last resort:

1) evaluate available data on NCS;

2) verify whether the Threshold of Toxicological Concern (TTC) can be applied;

3) verify whether the NCS risk assessment can be achieved on a component basis; and

4) determine whether data must be generated.

This webinar will show how these steps are used for all the endpoints to provide a comprehensive Safety Assessment of NCS used as a fragrance ingredient.