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Low-pass whole-genome sequencing combined with imputation is becoming a widely adopted tool for agricultural and companion animal genotyping and breeding applications. Compared to targeted methods, data produced with low-pass sequencing enables a more in-depth exploration of the genome to locate regions that may influence specific complex traits and provides accurate genomic predictions across subsets of species. Additionally, this method yields more information than traditional genotyping arrays and has significantly higher statistical power, allowing breeders to leverage their genotyping data for the discovery of rare genetic variants. Finally, combining low-pass sequencing with imputation yields more genotypes per dollar than other genotyping platforms.

On a commercial scale, high-throughput sequencing must meet the following objectives: 1) be dynamic to provide high-quality data, 2) have a rapid turnaround time for many applications, and 3) have low cost per gigabase to be competitive with other alternatives in the market.

This webcast will present how advancements in low-pass whole-genome sequencing, imputation, and sequencing hardware meet the goal of broadening access to high-quality whole-genome genotype data with a rapid turnaround time.

Learn how:

• Low-pass whole-genome sequencing can improve genotyping accuracy and depth across breeding populations
• SNP variants spanning the entire genome improve genomic selection or help discover newly identified, population-specific trait associations
• The Element AVITI^™ system can improve turnaround times, data quality, and data consistency for genotyping applications at a similar price to production-scale sequencers