Structure-guided design of SARS-CoV-2 antivirals

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Overview

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Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is spreading rapidly across the world and was announced as a “global pandemic” by the World Health Organization (WHO) on 11 March 2020.

SARS-CoV-2 is a new member of the betacoronavirus genus and closely related to severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Insights to the molecular basis for coronavirus recognition and infection holds promise for therapy.

Cryo-EM studies are now shedding light on key molecular processes including RNA replication/transcription and receptor recognition. These findings provide important insights to the molecular basis for coronavirus recognition, infection and ultimately, the design of new antiviral therapeutics.

The speakers will present the structural basis of:

Full-length ACE2 recognition by SARS-CoV-2
RNA-dependent RNA polymerase nsp12 in complex with cofactors nsp7 andnsp8
Design of Corona-targeting antiviral medicines

This webcast has been produced on behalf of Thermo Fisher Scientific who retains sole responsibility for content. About this content.

The overall structure of RBD-ACE2-B0AT1 complex

Presenters

Quan Wang

Assistant Professor, Principal Investigator
ShanghaiTech University
View Biography

Renhong Yan

Postdoctoral Researcher
Westlake University
View Biography

Dr. Jayshan Carpen

Moderator
Springer Nature
View Biography

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