Using immunosequencing to characterize HLA and its role in disease

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Using immunosequencing to characterize HLA and its role in disease

Available on demand

Overview

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Classic major histocompatibility complex (MHC) proteins, also known as human leukocyte antigen proteins (HLA) in humans, play an essential role in immune function and regulation, including influencing the composition of the T-cell repertoire. A growing body of research shows that a range of diseases, including autoimmune diseases, are linked to specific HLA alleles, suggesting that HLA type plays an important role in disease susceptibility.

Emerging research efforts such as Adaptive and Microsoft’s antigen mapping collaboration, are focusing on these associations as well as the role of HLA type in immune responses and immune-driven therapies.

In this webcast, Dr. Thomas Snyder and Dr. Jabran Zahid will discuss how immunosequencing and identification of public T-cell receptor responses can be used to characterize HLA type and make connections of HLA to disease biology, immune response, and immune-driven therapies.

Learn about:

The role of HLA proteins in the adaptive immune system
How HLA type impacts diseases such as autoimmune disease, cancer and infectious diseases
How immunosequencing can help reveal the role of HLA in disease, from association and susceptibility to detection and treatment

This webcast has been produced by Adaptive Biotechnologies, who retains sole responsibility for content. About this content.

Presenters

Dr. Thomas Snyder

VP of Research
Adaptive Biotechnologies
View Biography

Dr. H. Jabran Zahid

Senior Researcher
Microsoft Research
View Biography

Moderator: Sarah Hiddleston

Science Journalist
Nature Research Custom Media
View Biography