Derived and calculated lipid profile parameters play a crucial role in assessing an individual's cardiovascular health and risk of related diseases. The lipid profile, a standard blood test, traditionally includes measurements of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides. However, derived parameters go beyond these basic measurements, offering a more comprehensive understanding of lipid metabolism. Derived lipid profile parameters are mathematical calculations or ratios that provide additional insights into cardiovascular risk. Commonly used derived parameters, besides LDL-Cholesterol include the atherogenic index of plasma (AIP), non-HDL cholesterol (non-HDL-C), and the LDL-C to HDL-C ratio. These parameters help clinicians assess the balance between atherogenic and anti-atherogenic lipoproteins, providing a more nuanced evaluation of lipid-related cardiovascular risk. Calculating these derived parameters involves simple arithmetic operations using the standard lipid profile values. For example, the AIP is computed by dividing the logarithmically transformed ratio of triglycerides to HDL-C. Non-HDL cholesterol represents the cholesterol content of all lipoproteins except HDL and is calculated by subtracting HDL-C from total cholesterol. These calculations offer a more tailored approach to risk assessment, considering the interplay between different lipid components. Navigating the data generated by derived and calculated lipid profile parameters requires a thorough understanding of their clinical implications. Clinicians interpret these values in conjunction with traditional lipid profile results to refine risk stratification and guide personalized treatment strategies. As our understanding of lipid metabolism evolves, the importance of these derived parameters in cardiovascular risk assessment continues to grow. In conclusion, derived and calculated lipid profile parameters enhance the depth of information obtained from traditional lipid measurements, providing a more comprehensive view of cardiovascular risk. Navigating this data requires a nuanced understanding of the derived parameters and their clinical significance, empowering healthcare professionals to make informed decisions in managing and mitigating cardiovascular risk for their patients.

This webinar comprises of three following presentations of 20 min each followed by 20 min of panel discussion at the end.

Chair: Prof. Tahir Pillay

Talk 1- "Application of calculated LDL-cholesterol in the clinical laboratory" - Prof. Sridevi Devaraj

Talk 2- "Risk Assessment in Cardiovascular Disease using derived lipid profile parameters" - Prof. Patrick Twomey

Talk 3- "LDL-cholesterol vs Apo B: pros and cons?" - Prof. Andrew Don-Wauchope

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