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Cancer immunotherapy, including but not limited to immune-checkpoint inhibitors, has revolutionized cancer treatment in the last decade and there is a continuous expansion of immuno-oncology pipeline drugs and active clinical trials. In this scenario, antibody development for cancer therapy is a major priority for the immune-oncology field. For this webcast, we have brought together experts to discuss approaches to identify novel targets of interest and to develop antibodies and therapeutic proteins for cancer immunotherapy, with a focus on manufacturing, antibody engineering and optimization.